Systems Biology and Biotechnology Capstone

Start Date: 06/02/2019

Course Type: Common Course

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About Course

NOTE: In order to take this course you should have taken and complete the following courses in the Signature Track: Introduction to Systems Biology, Network Analysis in Systems Biology, Dynamical Modeling Methods for Systems Biology, Experimental Methods in SB and Integrated Analysis In Systems Biology

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Course Introduction

NOTE: In order to take this course you should have taken and complete the following courses in the S

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Synthetic biology Synthetic biology is an interdisciplinary branch of biology and engineering. The subject combines various disciplines from within these domains, such as biotechnology, evolutionary biology, genetic engineering, molecular biology, molecular engineering, systems biology, biophysics, and computer engineering.
Open Biology Submitted content is categorized under the following subject areas: biochemistry, bioinformatics, biophysics, biotechnology, cellular biology, developmental biology, genetics, genomics, immunology, microbiology, molecular biology, neuroscience, structural biology, synthetic biology and systems biology.
Biotechnology The wide concept of "biotech" or "biotechnology" encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms such as pharmaceuticals, crops, and livestock. As per European Federation of Biotechnology, biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services. Biotechnology also writes on the pure biological sciences (animal cell culture, biochemistry, cell biology, embryology, genetics, microbiology, and molecular biology). In many instances, it is also dependent on knowledge and methods from outside the sphere of biology including:
Systems biology The formal study of systems biology, as a distinct discipline, was launched by systems theorist Mihajlo Mesarovic in 1966 with an international symposium at the Case Institute of Technology in Cleveland, Ohio, entitled "Systems Theory and Biology".
Systems biology Systems biology is the computational and mathematical modeling of complex biological systems. An emerging engineering approach applied to biological scientific research, systems biology is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionism) to biological research. Particularly from year 2000 onwards, the concept has been used widely in the biosciences in a variety of contexts. The Human Genome Project is an example of applied systems thinking in biology which has led to new, collaborative ways of working on problems in the biological field of genetics. One of the outreaching aims of systems biology is to model and discover emergent properties, properties of cells, tissues and organisms functioning as a system whose theoretical description is only possible using techniques which fall under the remit of systems biology. These typically involve metabolic networks or cell signaling networks.
Synthetic biology Engineers view biology as a "technology" – a given system's "biotechnology" or its "biological engineering". Synthetic biology includes the broad redefinition and expansion of biotechnology, with the ultimate goals of being able to design and build engineered biological systems that process information, manipulate chemicals, fabricate materials and structures, produce energy, provide food, and maintain and enhance human health (see Biomedical Engineering) and our environment.
Molecular Systems Biology Molecular Systems Biology is an open-access peer-reviewed scientific journal publishing research within systems biology at the molecular level, including genomics, proteomics, metabolomics, microbial systems, the integration of cell signaling and regulatory networks, and synthetic biology.
Systems and Synthetic Biology Systems and Synthetic Biology is a peer-reviewed scientific journal covering systems and synthetic biology. It was established in 2007 and is published by Springer Science+Business Media. The editors-in-chief are Pawan K. Dhar (University of Kerala) and Ron Weiss (Massachusetts Institute of Technology).
Gautam Buddha University School of Biotechnology Areas for Research: Animal Biotechnology, Plant Biotechnology, Bioinformatics, Cell and Molecular Biology, Structure Biology and Biochemistry
Capstone Program Within Alaska, Capstone linked several initiatives to coordinate between the FAA, community, and industry. Capstone outlined the process and scope for upgrading the operating infrastructure with airports, weather products, communications, and GPS-driven systems.
Systems biology Around the year 2000, after Institutes of Systems Biology were established in Seattle and Tokyo, systems biology emerged as a movement in its own right, spurred on by the completion of various genome projects, the large increase in data from the omics (e.g., genomics and proteomics) and the accompanying advances in high-throughput experiments and bioinformatics.
Molecular Systems Biology According to the "Journal Citation Reports", the journal had a 2014 impact factor of 10.872, ranking it 10th out of 289 journals in the category "Biochemistry & Molecular Biology". The journals citing "Molecular Systems Biology" most often were "PLoS ONE, BMC Systems Biology, Molecular Systems Biology, PLoS Computational Biology", and "Proceedings of the National Academy of Sciences".
New Biotechnology New Biotechnology is a peer-reviewed scientific journal and the official journal of the European Federation of Biotechnology. It is published bimonthly by Elsevier. The journal covers research, industrial, and commercial aspects of biotechnology, in areas such as: healthcare and pharmaceuticals; food and agriculture; biofuels; genetic engineering and molecular biology; genomics and synthetic biology; nanotechnology; environment and biodiversity; biocatalysis; bioremediation; andprocess engineering.
Systems biology This variety of viewpoints is illustrative of the fact that systems biology refers to a cluster of peripherally overlapping concepts rather than a single well-delineated field. However the term has widespread currency and popularity as of 2007, with chairs and institutes of systems biology proliferating worldwide.
Systems biology The 1960s and 1970s saw the development of several approaches to study complex molecular systems, such as the metabolic control analysis and the biochemical systems theory. The successes of molecular biology throughout the 1980s, coupled with a skepticism toward theoretical biology, that then promised more than it achieved, caused the quantitative modelling of biological processes to become a somewhat minor field.
Systems biology Cancer Systems Biology is an example of the systems biology approach, which can be distinguished by the specific object of study (tumorigenesis and treatment of cancer). It works with the specific data (patient samples, high-throughput data with particular attention to characterizing cancer genome in patient tumour samples) and tools (immortalized cancer cell lines, mouse models of tumorigenesis, xenograft models, Next Generation Sequencing methods, siRNA-based gene knocking down screenings, computational modeling of the consequences of somatic mutations and genome instability). The long-term objective of the systems biology of cancer is ability to better diagnose cancer, classify it and better predict the outcome of a suggested treatment, which is a basis for personalized cancer medicine and virtual cancer patient in more distant prospective. Significant efforts in Computational systems Biology of Cancer have been made in creating realistic multi-scale "in silico" models of various tumours.
Systems biology An important milestone in the development of systems biology has become the international project Physiome.
Systems biology Other aspects of computer science, informatics, statistics are also used in systems biology. These include:
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Institute for Systems Biology ISB currently hosts 10 research groups with expertise ranging across genetics, microbial genetics, complex molecular machines, macromolecular complexes, gene regulatory networks, immunology, molecular and cell biology, cancer biology, genomics, proteomics, protein chemistry, computational biology and biotechnology. The ISB web site lists 985 peer-reviewed publications for the years 2000 through early 2012.